The comparison of the effects of dexmedetomidine, fentanyl and esmolol on prevention of hemodynamic response to intubation

A study out of Turkey…

Curious to see how this works in our ASA 3 and 4 CABG cases.

The comparison of the effects of dexmedetomidine, fentanyl and esmolol on prevention of hemodynamic response to intubation.
Rev. Bras. Anestesiol. vol.64 no.5 Campinas Sept./Oct. 2014

Advertisements

Blunting hemodynamic response to tracheal intubation #anesthesia

2% Lidocaine HCl preparation, pre-filled AbboJ...
Image via Wikipedia

https://secure.muhealth.org/~ed/students/articles/AnesthAnalg_72_p0482.pdf

This is an older study done that looked at placebo, lidocaine, fentanyl, and esmolol to blunt the effects of tracheal intubation/DL that typically occurs with it.  They looked at MAP/SBP and HR.  From their data, it appears that esmolol is the winner.  However, the doses of medication were not titrated to body weight.  It seems that everyone got the same dose.  Also, looks like everyone received pancuronium, a nice cardioaccelerator.  But, for what it’s worth, I can see using esmolol on pt’s who need perfect HR/BP control and no CHF.