TAVR Team: conscious sedation vs. general anesthesia

Today, we had a guest speaker Christian Spies from Queen’s Hospital in Hawaii who spoke on his experience with his TAVR team and conscious sedation vs. general anesthesia for these patients.  More specifically, we are speaking of the transfemoral route.

Keypoints:

  • Patient selection is key (consider for COPD; bad for OSA)
  • Short surgical time for monitored anesthesia care (MAC)
  • Decrease invasive monitoring (no PA catheter,+/-CVP)
  • No difference in hospital LOS or 1 year mortality rate
  • Move from TEE to TTE if MAC
  • Be prepared to convert MAC to GA (can be difficult in already tenuous patient in a crowded space under the drapes)
  • MAC agents: dexmetetomidine, propofol, ofirimev
  • Decrease pressor use
  • Develop an algorithm for MAC vs. GA and patient selection

From goinggentleintothatgoodnight.com

For my own lit search:


***Update May 1, 2018***

We at Scripps Memorial Hospital in La Jolla do most of our transfemoral TAVRs via conscious sedation assuming appropriate patient selection.  These patients still tend to be the inoperable patients not cleared for open heart AVR (aortic valve replacement).  My techniques and choices for setup have changed over time as I’ve had a chance to fine-tune my plan based on prior experiences with TAVR.  Patients typically come to the hybrid room with a 20g PIV placed by the pre-op RN.

My Setup:

  • 4 channel Alaris pump:
    • dexmedetomidine @ 0.7 mcg/kg/hr until incision –> 0.4 mcg/kg/hr until valve deployment –> off
    • norepinephrine @ 2 mcg/min (titrating on/off, up/down as vitals suggest)
    • Isolyte (IV carrier fluid) @ 200ml/hr until valve deployment –> 50ml/hr
  • Cordis neck line
    • Initially, I would have the interventional cardiologist setup a femoral venous line since they’re getting access to the groin.  However, the cardiologist would use that femoral line for emergent ECMO cannulation and I would lose my venous access and have to depend on a measly 20g PIV.  Nowadays, I try for a short 14g or 16g PIV.  If I can’t get one, the patient gets an awake right IJ cordis for large venous access.
  • Hot line fluid warmer with blood-Y tubing: this is for hookup to a large PIV or cordis line
  • Right radial arterial line
    • I started only placing right radial arterial lines because there was a case of a dissection and I immediately lost my left radial arterial line and couldn’t do pressure monitoring.  I insist on only using the RIGHT radial for my arterial monitoring.  Do not let the cardiologist only give you arterial monitoring based on their femoral arterial access.  It will only give you intermittent monitoring and there are critical points leading up to the deployment where you need CONTINUOUS arterial monitoring.  Therefore, I’ve found the right RADIAL arterial line best for continuous monitoring.
  • Facemask for continuous oxygen at 10L/mim with ETCO2 monitoring
  • For trans-subclavian/axillary approach vs. transfemoral approach TAVR, I’ll put in a supraclavicular block right after Cordis/large-bore PIV venous access for patient comfort while still utilizing conscious sedation/MAC.

My Technique:

  • When the patient gets to the room, transfer patient to OR table.  Start IV fluids @ 200ml/hr.  Cases that go well are about 2 hours from start to end.
  • Facemask O2 at 10L/min.
  • Start sedation: precedex/dexmedetomidine @ 0.7 mcg/kg/hr.  Some patients may receive 1-2mg midazolam x 1 and 25-50mcg fentanyl for radial art line placement.
  • Place right radial art line with lidocaine for skin numbing.  Place PIV with lidocaine.  If unable to get access for PIV, prep neck –> sterile gown/glove/drapes for U/S guided Cordis placement with lidocaine.
  • OR staff preps patient.  Antibiotics prior to incision.
  • At incision –> precedex to 0.4 mcg/kg/hr.  25-50mcg fentanyl PRN discomfort. 10-20mg propofol push for discomfort if needed while large sheath placed for valve deployment.
  • Crossing valve –> BP changes.  Manage with volume or levophed.
  • Valvuloplasty
  • Don’t treat over-drive pacing too aggressively when the valve is deployed.  Typically, once the new valve is in, a little volume will help normalize the BP.
  • Once valve is deployed, turn precedex off.  No other sedation or BP meds needed.  Change IVF rate to 50ml/hr.
  • Patient heads to PACU awake, interactive, and comfortable.

What techniques do you like to do?  Any suggestions on a different approach?

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Mr. Chill

CPR training
Image via Wikipedia

Feb 17, 2011

Today was an ordinary day.  Come in for a minimally invasive aortic valve and call it a day.  However, that case was cancelled secondary to UTI.  So, I opted to get involved in a different case…. an epicardial lead placement.  This was a gentleman I’ll refer to as Mr. Chill.  He was getting an epicardial lead placement b/c he was in heart failure and was going to undergo CRT.  He already had RA/RV leads and AICD.  He was a rather obese gentleman (280lb, 5’6″).  He had a history of amphetamine induced cardiomyopathy with an EF of 18%, inferior wall infarct and ant-sept wall infart, LV dilatation.  There was noted coronary sinus stenosis hence the need to abandon a coronary sinus lead and just go for the epicardial lead that would be placed via thoracotomy.  Aside from his heart history, he also had DM, HTN, AFib, sleep apnea (not using CPAP).  He’s on a whole host of meds… preop echo showed EF20%, severely decreased LV systolic function, hypokinesis of LV/RV, mild MR/TR, mod pulm HTN.

I met Mr. Chill in the pre-op holding area while a resident and CRNA were attempting to place PIV.  I took a look and you really can’t see anything.  So, while they were bringing the U/S, I was able to get a 22G PIV — not worthy of cardiac surgery…but worthy for induction.  A right radial a-line was placed with some difficulty (imagine poor EF…difficult to feel pulsatility anywhere).  The AICD rep was supposed to be available, but was running late so we were given the green light to go back to the OR.  The reason he earned the name Mr. Chill was b/c he was very relaxed and very interactive with us during PIV and a-line.  Every now and then he’d doze off, but then we’d say his name and he’d wake back up and interact with us.  I’m thinking that’s probably a combo of his OSA and his low flow state.

We brought him back to the OR, placed monitors on him.  The EKG appeared to be a wide complex regular sinus rhythm…someone who appeared to have a LBBB.  His a-line was reading 110-110SBP.  We were pre-oxygenating him for awhile.  Induction: lido 100mg, fentanyl 150mcg, etomidate 20mg, roc 70mg…after induction he stayed in the SBP90s.  Slowly, he started to drift down while taking over mask ventilation.  Luckily, he was an easy mask.  Now his SBP 80s, we intubate with a L DLT.  Confirmed with ETCO2.  SBP hanging in the 70s…multiple boluses of phenylephrine (total 600mcg), ephedrine (30mg), epi (100mcg) the SBP would go up to low 80s, but come back down to 70s.  We checked the DLT via FOI…it seemed a bit deep, therefore we pulled it back.  Still, we weren’t happy with it and his SBP was sagging, therefore, we took out the DLT and reintubated with an 8.0ETT.  Pt was oxygenating well as the SpO2 read 96-98%.  Then, his radial aline went to 60s. We cycled NIBP that showed 50s/20s.  Then the art line went flat.  We started CPR, 1mg EPI followed by atropine.  With CPR, the arterial trace looked good reading a pressure in the 80s.  PEA was suspect…we ran serial ABG, got femoral access.  We came out of it.  First ABG showed CO2 70s…ETCO2 was in the 40s.  We hyperventilated him and started him on an epi infusion.  The AICD rep interrogated his AICD…and we found out that the patient had 4 episodes of VT that was treated by overpacing from the AICD (not shocks).  This occurred in the pre-op area prior to going back to the OR and lasted for 35 seconds total.

We cancelled the case and took the patient to the SICU.

Things I took away from this case:

1) Always have the AICD rep interrogate prior to going to OR.  Period.  It doesn’t matter if everyone in the OR wants you to go… it’s worth waiting.  Obviously, Mr. Chill didn’t show any signs of VT to us b/c we were with him in the pre-op area.  There were no shocks delivered from the AICD.  Had I known he had 4 consecutive VT episodes that were worthy of AICD treatment via pacing, I’d have cancelled the case prior to going back to the OR.  Done!

2)  With an EF hanging around 10%, this guy is probably living off his sympathetic tone.  Do NOT give fentanyl, even if you think he may get tachycardic from the intubation.  Give it as it’s needed…even though it’s “cardiac stable”.  No one is stable with an EF10%.  The last thing I want to do is decrease any tone that may be supporting him. (Sure, maybe it’s a placebo for me… so be it!)

3) This guy’s PEA was most likely caused by hypercarbia.  He had a history of OSA and would intermittently fall asleep in the pre-op holding area… he may have been hypoventilating.  We didn’t see it on the ETCO2 trace while masking him b/c he probably has a large A-a gradient (ETCO2 registered on our monitors was 45).  His lungs are getting well ventilated…but his circulation time is so slow that he’s underperfused.  Dead space… and a lot of it.

4) For a guy like this, make sure surgeon and perfusionist are present in the room on induction.  They were present here…just an FYI.

5) R2 pads are always good to have in place, just in case.  Yes, this guy has an AICD… but at some point the treatment/shock mode will be turned off for the surgery.

6) Go with your gut instinct.  If your gut is telling you that he needs some beta activity to get the heart jumpy enough to tolerate induction… then do it.

7) Be a calm, cool cucumber during the resuscitation.  Our team did a fabulous job of communicating and getting things done… all b/c of clear, concise communication.  It really does make a difference.

8) Debrief.  This helps get everything on the table and brainstorm what could have been done differently or better.  We’re all colleagues; no one has room  to pass judgment.  Ever. (If they do, take’em out back and kick ’em in the shins!)

Calm before the storm

People who have witnessed and/or survived crazy forces of Mother Nature often state that there’s a “calm before the storm”. I have experienced this with tornados growing up in west Texas.

But on OB?
Yep.

The OB anesthesia team was enjoying the fruits of the night team’s labor. All epidurals were in…. most of the ladies had delivered. Life was good! I even had time to prop my feet up and get some reading done. Not only that, we all enjoyed a rather relaxed lunch. It was WAY TOO CALM!!!

Anesthesia stat was called overhead/paged to our beepers/called to the anesthesia room….
What appeared to be a normal vaginal delivery… turned into any OB’s worst nightmare. The cause wasn’t clearly revealed. We started multiple large bore IVs and sent off blood and raced to the OR. EBL 3L. Once in the OR, complete assessment of the bleeding by the OBs rendered a necessary hysterectomy. The patient was pale white…never before had I seen a human being so pale, but alive and interacting with us. She didn’t flinch for a 14g PIV or the a-line. I wonder what she was thinking as she could probably feel her life fading away. Belmont, cardiac nurses, cell saver..dozens of people in an OB OR; all wanting to give this woman a chance to see her 5 kids.

PreOX, Cricoid, RSI–>GA. Quick prep. Intraop, a uterine rupture was noted. Hysterectomy completed. Still more bleeding!! Multiple uterine veins were found…just avulsed along the lateral walls of the abdomen. 2 more ob/gyn surgeons called stat for repair. Still no control of the bleeding. Partial aortic compression to help with hypotension. 2 vascular surgeons called. + Confirmation of control of bleeding. Belmont was running about 200ml/min x 120 min. Multiple blood product given (20-30U PRBC, 20-30U FFP, 24 plt, 10 cryo). pH 7.11–>7.38. UOP about 100ml/hr. At it’s lowest, Hb was 4.8 (the lowest I’ve ever seen!). Upon delivery to the unit, pH 7.38, Hb 10, Plt 127 (got as low as 84), PT/PTT slightly elevated, INR 1.2 (1.8 at its highest), fibrinogen 213 (65 at its lowest). She was mechanically ventilated based on the ARDSnet protocol (small tidal volumes, higher PEEP, fast frequency).

This is not something you see everyday…. much less something you see commonly on OB. The wonderful communication between the nurses, surgeons, staff, anesthesia…everyone truly made this a world-class effort. And because of this… a mother cheated death.

Lessons learned:
– Call for help early and clearly
– Practice effective communication
– Close the loop — verify if questions
– Don’t be afraid to get help — there’s many consultants at a hospital…
– Debrief — because you’ll never know when you’ll need to be prepared for another “storm”